During the past three decades, the usage of herbal medicines and supplements has grown significantly, with at least 80% of people turning to them for some aspect of primary healthcare. Although the efficacy of many herbal medications has been proven, treatments utilizing these compounds have shown remarkable promise. Nevertheless, many of these drugs remain untested, and their usage is either inadequate or not at all regulated. As a result, it is difficult to advocate the safe and sensible use of these agents since little information is available about their mechanism of action, potential adverse responses, contraindications, and combinations with already available conventional medications and functional foods.
As safety is still a major concern when using herbal treatments, it is crucial that the proper regulatory agencies put in place the necessary safeguards to protect public health by ensuring that all herbal medications are secure and of high enough quality. In addition to outlining some significant difficulties in conducting an efficient safety evaluation of herbal medicinal products, this review examines toxicity-related issues and significant safety concerns resulting from their usage.
The state of herbal medicine today and the future of it
It has been estimated that 70% of all medical professionals in France and Germany frequently prescribe herbal medication, demonstrating that the widespread use of herbal therapy is not just limited to underdeveloped nations. Patients are increasingly turning to herbal therapies as a kind of treatment. The market for herbal goods is flourishing as a result of the US Food & Drug Administration (FDA) loosening standards for the selling of herbal supplements. According to the figures that are now accessible, the European Union’s herbal medicine industry was worth over $6 billion in 1991 (it may be over $20 billion now), with Germany accounting for $3 billion, France for $1.6 billion, and Italy for $0.6 billion. The American herbal medicine business was worth roughly $4 billion in 1996; by the year 2000, it had quadrupled. Over $1 billion worth of herbal drugs is sold in India, while roughly $80 million worth of crude herbal extract is exported.
A fascinating development has occurred in herbal therapy during the past few decades. It has made a reappearance rather than being eradicated by medical research and pharmaceutical chemistry. Herbal remedies and effective plant medicine have been acknowledged as a result of the objective examination of medical research, which has eliminated irrational and emotional claims for herbal cures. Moreover, research has revealed some excellent qualifications for herbal medicine. Although empirically developed via trial and error, many herbal remedies were astonishingly successful. According to a recent survey, 60–80% of antibacterial and anticancer medications were derived from natural materials, and 39% of the 520 new pharmaceuticals that were authorized between 1983 and 1994 were natural goods or derived from natural products.
Issues Must Be Fixed Before Using Herbal Medication Becoming Commonplace
There are a number of challenges to be resolved before herbal products with guaranteed quality and effectiveness may be included in standard medical therapy. As a result of not learning about phytomedicines throughout their academic programs and believing that they are all ineffectual, the bias of already employed healthcare professionals creates a barrier. The effectiveness of plant extract must persuade orthodox medical professionals. Equally stubborn are the beliefs of certain traditional herbalists who hold that unprocessed natural goods are inherently superior and that standardization and extraction will somehow damage the mysterious aura around plants. To quickly find and isolate a pharmacologically active chemical, it is helpful to leverage folk beliefs and traditional healers’ knowledge. To combat “piracy” by both Indian and international pharma corporations, however, intellectual property laws should safeguard tribal and traditional knowledge.
The quality of the literature on the field is a significant obstacle that must be solved. Misinformation abounds in books, pamphlets, journals, and especially the Internet these days. Most of it is written to sell products, and some of it is produced to convey a point of view based on wishful thinking rather than reality or disinformation. Few sites discuss regulation, safety, or efficacy; most only list plants and their applications. There may not even be a warning label on a plant like an ephedra, despite its well-known toxicity.
Another issue is that doctors using herbal remedies are often unaware of the need for optimal doses because it isn’t defined in the published papers and they are still relatively inexperienced with them. When practitioners accept the quality of a tampered-with or incorrectly-identified herb at face value, several false and unreproducible findings have been reported in the medical literature. The botanicals in the tested product are also frequently not identified precisely, or by scientific name, together with the precise dosage used.